Losmapimod (GW856553X) is an investigational drug that reached stage III clinical trials for multiple medical conditions, but did not prove efficacy. It was most recently in development by Fulcrum Therapeutics for the treatment of facioscapulohumeral muscular dystrophy (FSHD). Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression and mediators of inflammation.
"}{"slip": { "id": 112, "advice": "It's not about who likes you, it's about who you like."}}
{"slip": { "id": 158, "advice": "Life can be a lot more interesting inside your head."}}
{"slip": { "id": 77, "advice": "Mercy is the better part of justice."}}
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{"type":"standard","title":"Treeton","displaytitle":"Treeton","namespace":{"id":0,"text":""},"wikibase_item":"Q1616626","titles":{"canonical":"Treeton","normalized":"Treeton","display":"Treeton"},"pageid":1656012,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d1/Treeton_Terrace.jpg/330px-Treeton_Terrace.jpg","width":320,"height":240},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/d/d1/Treeton_Terrace.jpg","width":640,"height":480},"lang":"en","dir":"ltr","revision":"1244499226","tid":"a4ea3aac-6d1f-11ef-a78c-5ce053779359","timestamp":"2024-09-07T13:46:55Z","description":"Village and civil parish in South Yorkshire, England","description_source":"local","coordinates":{"lat":53.384501,"lon":-1.351273},"content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Treeton","revisions":"https://en.wikipedia.org/wiki/Treeton?action=history","edit":"https://en.wikipedia.org/wiki/Treeton?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Treeton"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Treeton","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Treeton","edit":"https://en.m.wikipedia.org/wiki/Treeton?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Treeton"}},"extract":"Treeton is a village and civil parish of the Metropolitan Borough of Rotherham in South Yorkshire, England. It is located about 4 miles (6 km) south of the town of Rotherham and 5 miles (8 km) east of Sheffield City Centre.","extract_html":"
Treeton is a village and civil parish of the Metropolitan Borough of Rotherham in South Yorkshire, England. It is located about 4 miles (6 km) south of the town of Rotherham and 5 miles (8 km) east of Sheffield City Centre.
"}{"slip": { "id": 222, "advice": "Respect other people's opinions, even when they differ from your own."}}
{"slip": { "id": 66, "advice": "Take time once in a while to look up at the stars for at least 5 minutes, in order to comprehend your cosmic significance."}}
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